Insulin Without Needles

Needle phobia is the Achilles heel of Insulin compliance. Not just for children, many adults also hate piercing their skin with an injection. InsuLife is on a mission to change this with Levellor™, an investigational medicinal transdermal spray-on insulin.
The Future of Insulin Delivery
Levellor aims to be the first transdermal spray-on Insulin. Sprayed directly onto the skin, Levellor eliminates the use of needles. The target of this breakthrough product:
  • Eliminates multiple injections per day
  • Room temperature stable, requiring no refrigeration
  • Potential for better patient compliance
  • Utilizes unmodified human insulin, a “commodity” drug product enabling cost competitiveness

Transdermal Delivery

The ability to transport a drug molecule through the skin is controlled by the dipole moment in a solution of the drug.

Substances which go through the skin readily have approximately the same dipole moment, and HSP has developed solutions that enable managing for the dipole moment so that the drug can be absorbed through the skin.

The solvents used are ethanol and fatty alcohols, a total of 99%. The last percentage of the solvent consists of a proprietary mixture of 15-20 naturally occurring substances that are chosen for purpose to impact the solution dipole moment. All of these substances are considered safe food additives or nutritional supplements and are defined as "Generally Recognized as Safe" (GRAS) by the US Food and Drug Administration (FDA).

How does the Insulin Molecule Enter Through the Skin?

During the InsuLife update seminar held on December 8th, 2022, an audience member raised the question: since the insulin molecule is so big, how does your spray technology manage to enter through the skin and not have to use a needle? Watch our Chief Science Officer, Dr. Chandan Alam, explain how it works.
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InsuLife is a Norwegian company aiming at bringing the unparalleled developmental Levellor™ spray-based insulin to market.
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